Journal: Scientific Reports
Article Title: Cladosporium cladosporioides , endophyte of Strelitzia nicolai , as a new producer of Alternariol monomethyl ether with a potential cytotoxic activity
doi: 10.1038/s41598-025-33343-6
Figure Lengend Snippet: Antiproliferative, anti-tubulin polymerizing, and anti-Topoisomerase I and II activities of the purified C. cladosporioides. ( A ) The IC50 values of purified AME against the MCF7, HepG-2 cells, A549 and normal OEC cells, compared to Taxol as a positive control. ( B ) Kinetics of Tubulin inhibition by the purified AME, normalized to CA4 as a reference drug. C, Kinetics of Topoisomerase I ( C ) and II ( A ) inhibition at different concentrations of C. cladosporioides AME .
Article Snippet: The human HepG-2 (ATCC HB-8065), A549 (ATCC CCL-185), and MCF7 (ATCC HTB-22) cell lines were obtained from the American Type Culture Collection.
Techniques: Purification, Positive Control, Inhibition